spain_flag  Madrid, Spain


History and Structure

Health Technology Assessment Agency (AETS) is a National Agency founded in 1994 as a Centre within the Institute of Health Carlos III (ISCIII). ISCIII is the main Public Research Entity funding, managing and carrying out biomedical research in Spain reporting to Ministry of Economy, Industry & Competitiveness and providing scientific and technical support to the Ministry of Health and to the National Health System (NHS).

AETS is working in coordination with the Spanish Regional HTA Agencies and Units in the Spanish HTA Network. ( Health technologies are prioritized for assessment in the Inter-territorial Health Council in the MOH. The Spanish HTA network is dealing with the assessment and is composed of 8 agencies


The main goal of the AETS is to promote the appropriate use of health technologies, providing decision-makers with critically review information about their efficacy, safety, effectiveness and efficiency.

Our objectives include the following:

  1. Establish – on scientific grounds – the medical, social, ethical and economic impact of the use of health technologies
  2. To promote the appropriate use of existing technologies.
  3. To contribute to the appropriate training of health professionals in health technology assessment.

How AETS Works

AETS plays a relevant role in supporting systematic reviews on health technologies at the national level. All of our HTA reports include internal and external reviews and are always based on the best available scientific evidence.  Systematic reviews are our main product.

The activities of AETS embrace the next areas:

  1. Health technology assessment reports (elaborating reports assessing the impact of health technologies)
  2. Research projects (in research areas as health services research and HTA)
  3. Coordination of evaluation services (participating in activities related with HTA advising NHS authorities).
  4. Postgraduate medical education programs through residential activities.

Dissemination Activities

Our assessment reports are mainly in Spanish, including always an abstract in English
Some of our reports are published in scientific journals or institutional publications.
Active participation in meetings of scientific and professional societies, short-term training courses for healthcare managers and clinicians with managerial responsibilities are means of disseminating AETS results.
Our HTA reports can be downloaded from our webpage or from the Spanish HTA Network webpage:

Current Projects (a selection):

  • Analysis of the usefulness and efficacy of oocytes cryopreservation in oncological patients
  • Efficacy and safety of adhesive endovascular treatment in varicose veins of lower limbs
  • Efficacy and safety of orthodontic maxillary expansion devices as an alternative to adenotonsillectomy and/or pharmacological treatment in the management of sleep apnea hypopnea syndrome in pediatric patients
  • Occluder device of left atrial appendage
  • Biodegradable esophageal stent for benign pathology
  • Post-polio syndrome: Review of the literature, Spanish situation and possible lines of action
  • Effectiveness, safety and indications of the Acoustic Radiation Force Impulse (ARFI) vs Fibroscan
  • Effectiveness, safety and indications of endoscopic ultrasound (EUS) vs shear wave elastography (SWE).
  • Quality criteria and good practices of the Spanish HTA Network
  • Guideline for the elaboration of recommendations and appropriate use criteria in health technologies

Also, we are involved in:

  • The European Joint Action 3 on HTA (EUnetHTA) as member of the Executive Board, Lead Partner of the Work Package 2, and Associated Partner of the WP 4, 5 and 7
  • The European Joint Action on  Chronic Diseases (CHRODIS-PLUS)
  • The Spanish Health Services Research on Chronic Patients Network (REDISSEC)
  • The Spanish information network for identification, prioritization and early assessment of new and / or emerging health technologies detection system.

Future Plans

  • To improve dissemination of HTA findings
  • To increase participation of care professionals and patients inside the HTA projects
  • To contribute to national and international collaboration on HTA


Agency Information:

Country: Spain
Description of population served: National
Population served (mil): 46
Current HTA budget (mil USD): AETS has not specific budget.  The budget for HTA activities is allocated in global ISCIII budget. The ISCIII’s budget is not divided among their centres.
Permanent staff: 14. No permanent staff for research projects.
Consultants: Variable
Ongoing TA projects:

Contact Information:

Contact person: Luis M. Sánchez Gómez

Health Technology Assessment Agency (AETS)
Dept. of International Research Programmes and External Relations  
 “Carlos III” Institute for Health (ISCIII)
Avda Monforte de Lemos 5. Pabellón 4
Madrid 28029

Tel: +34 91 8222005
Fax: +34 91 8222922